TFN Nicotine

Tobacco Free Nicotine


Liquid Nicotine Wholesalers is the official USA supplier of TFN® Nicotine and TFN® Nicotine solutions in a wide range of concentrations. From pure synthetic nicotine to 100mg synthetic e liquid nicotine that require dilution by the purchaser before inclusion into your DIY vape juice recipes, we offer only high-quality products at the most affordable prices.

TFN® remains the market leader in the supply of quality, USP synthetic nicotine. Over the past 5 years, the TFN® brand has defined the market by total sales, product quality, price competitiveness, and representing the desire of adult consumers to move away from all forms of tobacco-derived nicotine contained in many vaping products.

TFN® R-S nicotine has been produced for the US market since 2014. The product has an established track history with vape manufacturers, having been used in over 50 vape brands during that time.

Vape consumers have shown a high satisfaction and preference for TFN® products containing R-S nicotine. The growth and popularity of TFN® is reflected in its wide acceptance by the vape community in the USA. Adult consumers find TFN® R-S nicotine to be indistinguishable from tobacco-derived nicotine, and s-isomer synthetic nicotine, both in terms of overall satisfaction and taste. In fact, the taste and smell differences between the individual isomers of nicotine suggest that R-isomer plays an important role in moderating the harshness of all S-isomer nicotine, and perhaps contributes to the smoothness of R-S nicotine in vape products.

The underlying science on synthetic nicotine isomers is fast developing, and the framework for research is progressively focusing on the relative merits of combined R-S, and separated R and S isomers. The dated comparison of synthetic nicotine to tobacco-derived nicotine, and the relative isomer ratio in tobacco products, offers little insight into the neural pathway pick-up of the different forms of synthetic nicotine isomers. Further, the satiation pathways in the body relative to pick-up of R and S isomer nicotine may well differ to the extent that the isomers complement each other in achieving adult consumer satisfaction with R-S nicotine.

The suggestion that the R-isomer is somehow a so-called 'cheap filler' for synthetic nicotine, not only serves to undermine the potential opportunity that all of the isomeric forms of synthetic nicotine may have to contribute to adult consumers seeking to switch away from dominant tobacco-derived s-isomer nicotine products, but shows a failure to comprehend that synthetic nicotine technology has moved on from dated s-isomer biased tobacco science.

TFN® and Liquid Nicotine Wholesalers have been proud to take the lead in presenting adult consumers with the choice of a better nicotine, and the company remains committed to continuing the development of high quality nicotine offerings under the TFN® brand for years to come.

TFN® Nicotine

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